Selection bias and information bias in clinical research

Tripepi G, Jager KJ, Dekker FW, Zoccali C. Selection bias and information bias in clinical research. Nephron Clin Pract. 2010;115(2):c94-9. doi: 10.1159/000312871. Epub 2010 Apr 21. PMID: 20407272.


The internal validity of an epidemiological study can be affected by random error and systematic error. Random error reflects a problem of precision in assessing a given exposure-disease relationship and can be reduced by increasing the sample size. On the other hand, systematic error or bias reflects a problem of validity of the study and arises because of any error resulting from methods used by the investigator when recruiting individuals for the study, from factors affecting the study participation (selection bias) or from systematic distortions when collecting information about exposures and outcomes (information bias). Another important factor which may affect the internal validity of a clinical study is confounding. In this article, we focus on two categories of bias: selection bias and information bias. Confounding will be described in a future article of this series.

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